Brenda Hampton, a seasoned investigator, uncovers decades of pollution within her hometown, setting her on a path at odds with some of the world's largest corporations. Angel of Alabama is a call to action for the fight against "forever chemicals", which are growing into one of the biggest pollution crises in world history.

Firstborn of ten to a family in rural Alabama, Brenda was naturally inquisitive. Leaving home, she became a paralegal and then investigator but eventually returned to Lawrence County, Alabama due to her mother's health problems. An avid drinker of the local water, her mother's kidneys had crystallized and so Brenda donated a kidney to her. But eventually, Brenda's remaining kidney began failing which triggered her realization of a larger problem.

Nearby manufacturer, 3M, had been illegally dumping all manner of chemicals in the water for decades, which had contributed to the alarming rise of negative impacts to the local community's health.